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Synthesis of sea precursors

Référence

85777-01

Statut des brevets

French patent application FR0305569 filed on May 7, 2003 entitled “Synthesis of substituted heterocyclic compounds”

Inventeurs

Ali AL-MOURABIT
Nathalie TRAVERT
Said GHOULAMI
Robert ABOU-JNEID

Statut commercial

Exclusive or non-exclusive licenses and collaborative research

Laboratoire

Institut de Chimie des Substances Naturelles (ICSN), a CNRS laboratory, UPR 2301, in Gif-sur-Yvette, France.

Description

CONTEXT

It is known that compounds of following molecular structure in which A et B are heteroatoms and R is a substituent can be used for the synthesis of precursors of numerous natural products having properties of great interest, in particular in the pharmaceutical field, especially for the synthesis of alkaloids of marin origin, of azugar derivatives and of analogs of these products.

TECHNICAL DESCRIPTION

This invention provides a process for the production of these 5 membered heterocycles comprising two heteroatoms which are substituted, simple, cheap and with good yield, by opening biheterocycles of following structures.

INDUSTRIAL APPLICATIONS

– Rapid synthesis of natural precursors , for example of alkaloids of marine origin, such as hymenidin, chlathrodin and oroidin;

– New synthetic route for biogenetic precursors of products having therapeutic properties of great interest, in particular exhibiting immunosuppressant, antitumoral, antimicrobial and antiviral activities or also anticraving activity.

For further information, please contact us (Ref 85777-01)


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