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Quinolinones derivaties as smoothened agonists

Référence

03763-01

Statut des brevets

French patent application FR1004445 filed in November 16th, 2010 and entitled “Quinolinone derivatives”

Inventeurs

Martial RUAT

Statut commercial

Exclusive license

Laboratoire

Neurobiology and Development Laboratory (UPR3294), CNRS, in Gif-sur-Yvette, France.

Description

CONTEXT

The invention relates to compounds which are quinolinone derivatives capable of modulating the activity, in particular of including the differentiation, of stem and progenitor cells, these compounds are of use in the treatment of disorders related to stem to a stem differentiation defect; the invention also relates to novel compounds among these quinolinone derivatives and to pharmaceutical compositions containing the same. 

TECHNICAL DESCRIPTION

GSA-10 and related molecules stimulate a novel conformational form of Smo call SmoGSA-10 which is not targered to the primary cilium, does not increase the transcription of Hh target genes such as Gli1 and Ptc. 

INDUSTRIAL APPLICATIONS

– regenerative medicine
– obesity, diabetes
– neurodegenerative disorders

For further information, please contact us (Ref 03763-01)

 


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