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Process for reversible immobilization of biological macromolecules



Statut des brevets

French patent application FR0107700 filed on June 12, 2001 entitled “Procédé d’immobilisation réversible de macromolecules biologiques et dispositif pour sa mise en oeuvre”


Marie-Claude MILLOT
Christelle DAVID
Christelle RENARD

Statut commercial

Laboratoire de Recherches sur les Polymères (LPR), a CNRS and Université Paris XII laboratory (UMR 7581) in Thiais, France.



This invention describes a new process of non-covalent attachment of a protein (antibody, enzyme), DNA or specific fragment on a solid substrate: slides or beads (porous or non porous). The process can be extended to any kind of ligand: antigen, polysaccharide, specific ligand (drug, hormone, inhibitor). The ligand density and reproducibility is easily controlled. Due to the reversible character of the non-covalent binding, the process permits the release of immobilized molecules under soft conditions, allowing complete regeneration of the initial surface that can be used for new experiments.


Analytical applications: in sensors (slides or microarrays) using optical (surface plasmon resonance, ellipsometry) or spectroscopic (fluorimetry) detection, the immobilization of molecules bearing molecular recognition sites allows the detection and/or determination of specific antigens or antibodies, sDNA fragments, carbohydrates, proteins in proteomics or enzymes. The main interest of the process is the possibility of sensor regeneration.

Extractive applications: using beads, monoliths or fibers, the process can be extended to prepare selective or specific extractants of the compounds mentioned above. Applications to proteomics may be possible.

For further information, please contact us (Ref 84677-01)


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