CONTEXT

AIDS (Acquired Immune Deficiency Syndrom) pandemic is responsible of the death of an estimated 2,1 million people in 2007, inculing 330 000 children. In the same year, an estimated 33,2 million people worldwide lived with the HIV virus. At present, tritherapies including nucleosidic inhibitors (INTI like zidovudine (AZT)), non nucleosidic inhibitors (INNTI) and/or antiproteases (IP) allowed a notable decrease of the mortality caused by HIV virus’ infections. However, genotypes showing resistance against an antiviral are found in 80% of patients, and more worrying, 45,5% of viral populations are resistant to an association INTI/IP and 26% to an association of the three anti-VIH classes. Moreover, some side effects (lipoatrophies, lipodystrophies, hypertriglycidemy etc) appeared in 70% of patients. In this situation, it is necessary to explore other steps of HIV replicative cycle in order to develop an efficient treatment of AIDS.

TECHNICAL DESCRIPTION

The invention relates to the use of a composition containing a human plasmatic protein for the preparation of a new drug for the prevention or treatmentof diseases associated to viral infections, especially those caused by HIV1 or HIV2. This protein acts on a new target of the viral cycle and presents original performances of viral transcription inhibition with less supposed side effects. The invention also relates to a pharmaceutical composition and to an in vitro diagnosis method to asses the resistance to a viral infection in an biological sample.

BENEFITS

In addition to causing less side effects in patients with absence of resistance profile, this new protein should presents many advantages: Immunologically: this molecule is from human, so immunological risks are reduced Efficiency: according to tests carried by researchers, low doses of this protein (dozens of nM) allow the inhibition of HIV Originality: up to date, the transcription of HIV has been less explored. This protein inhibits this step of viral cycle at two levels: interaction with a human transcription factor and with Tat viral protein.

INDUSTRIAL APPLICATIONS

Preparation of a new antiviral treatment, particularly against HIV viruses, and a treatment against inflammation associated diseases.