Improvement of gene targetin efficiency by DNA chemical modification
Référence
85283-01
Mots-clés
DNA modification, Target gene, Homologous recombination, Gene therapy
Statut des brevets
French patent application FR0213474 filed on October 28th, 2002 entitled “Procédé pour insérer un acide nucléique d’intérêt dans une cellule procaryote ou eucaryote par recombinaison homologue”
Inventeurs
Marc BICHARA
Robert FUCHS
Statut commercial
Exclusive or non-exclusive licenses and collaborative research
Laboratoire
Laboratoire « Cancérogenèse et Mutagenèse Moléculaire et Structurale » (CMMS), a CNRS laboratory (UPR 9003) in Illkirch-Graffenstaden, France?
Description
TECHNICAL DESCRIPTION
This invention describes a process to increase gene targeting frequency in E. coli (factor 1 000 to 100 000). Chemical modifications result in DNA damage, blocking of DNA replication and improvement of homologous recombination efficiency.
This process allows gene targeting by integrating a modified gene in place of a healthy gene for the inactivation of said gene.
INDUSTRIAL APPLICATIONS
This innovation comes within the scope of functional genomic.
By allowing the activation or inactivation of target genes, it could represent a new tool for gene therapy.
For further information, please contact us (Ref 85283-01)
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