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Use of a cellular extract for a mitotic remodelling of chromosomes

Référence

00490-01

Statut des brevets

Provisional patent application US60/721978 filed on September 30, 2005, entitled « Use of a cellular extract for a mitotic remodelling of chromosomes”

Inventeurs

Marcel MECHALI
Jean Marc LEMAITRE

Statut commercial

Exclusive or non-exclusive licenses, Collaborative agreement

Laboratoire

Institut de Génétique Humaine (IGH), UPR1142 in Montpellier, France.

Description

CONTEXT

Nuclear transfer is a powerful method that can be used to produce cloned animals and to obtain new sources of multipotential cells from differentiated tissues. Blastocyst embryos can be obtained by transplanting nuclei from amphibian or mammalian cells into enucleated eggs.
The potential ability of this method to deliver supplies of multipotential cells opens new perspectives for cell-based therapies in numerous disorders.  However, nuclear transplantation is often inefficient due to the difficulty of completely reprogramming differentiated adult nuclei for the events of early development. Indeed, identifying the specific epigenetic properties of differentiated cell nuclei represents a challenge of major biological and medical significance.   

TECHNICAL DESCRIPTION

The present invention relates to the use of a female germinal cell (egg) extract of pluricellular organisms in M-phase of the cell cycle for a mitotic remodelling of chromosomes of donor cells of pluricellular organisms, wherein the mitotic remodelling confers to the nucleus of the aforesaid donor cells the ability to adapt themselves to the early embryonic development in order to carry out the embryonic development or to obtain stem cells. 

BENEFITS

This method of chromosomes mitotic remodeling allows to re-configure the DNA of the somatic cells and to place it in optimal situation for a later embryonic development. Thus, the invention can contribute to increase performances in animal cloning.  

INDUSTRIAL APPLICATIONS

Nuclear transfer is a powerful method that can be used to produce cloned animals and to obtain new sources of multipotential cells from differentiated tissues. This technology is also available for the suppliers of kits and laboratory reagents.

For further information, please contact us (Ref 00490-01)


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