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Polypeptides with a ß-adrenergic receptor activity involved in the lipolytic response

Référence

82250-01

Statut des brevets

French patent application FR8900918 filed on January 25, 1989 and entitled “Polypeptides ayant une activité de récepteur ß-adrénergique chez l’homme, impliquées dans la réponse lipolytique, acides nucléiques codant pour ces polypeptides et utilisation de ces polypeptides pour le criblage de substance active sur ces polypeptides”

Inventeurs

Marie Madeleine SUTREN
Arthur Donny STROSBERG
Stéfano MARULLO
Laurent EMORINE

Statut commercial

Non-exclusive licenses

Laboratoire

Institut Cochin de Génétique Moléculaire (ICGM, UMR8104), Paris, France.

Description

TECHNICAL DESCRIPTION

Researchers have identified a new receptor from the ß-Adrenergic family, called the ß-3 receptor which can be expressed in a host (unicellular such as E. Coli, cell lines such as CHO, etc…). ß-3 receptors are involved in the lipolly cell pathway, particularly in adipose cells, and in the control of energy balance. These receptors are mutated in some obese patients, suggesting that this could be a factor of genetic predisposition to obesity

INDUSTRIAL APPLICATIONS

Screening drugs with potential activity for treating obesity, Type II diabetes and hyperlipidemia.

 


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