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30.01.2020
11827-01
06.11.2018
Materials – Coating 07293-01
06.11.2018
Materials – Coating 10581-01
06.11.2018
Chemistry / Environment 08758-01
06.11.2018
11127-01
06.11.2018
Environment and Energy 11107-01
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86508-01
French patent application FR0408427 filed on July 20th, 2004 and entitled “Dérivés phospholes complexés à des métaux et leurs utilisations pharmaceutiques”.
Elisabeth DAVIOU-CHARVET
Katja BECLER-BRANDENBURG
Valérie DEBORDE
Régis REAU
Heiner SCHIRMER
Christel HEROLD-MENDE
Exclusive or non-exclusive licenses
Interdisciplinary Research Center, Giessen University, Germany
Biochemie-Zentrum, Heidelberg University, Germany
Department of Neurosurgery, Heidelberg University, Germany
UMR 6509, CNRS / Rennes 1 University, France.
This invention describes pharmaceutical compositions containing phosphole derivatives complexed with gold or platinium and their use in particular for the prevention or treatment of pathologies associated with an excess activity of human glutathione reductase and/or thioredoxin reductase. These components act as irreversible inhibitors of glutathione and thioredoxin reductases.
– Prevention or treatment of cancers, rheumatoid polyarthritis, psoriasis or Sögren syndrome.
– Prevention or treatment of resistance to anti-cancerous drugs.
The anti-tumour activity of this pharmaceutical composition was tested in vivo on rat and showed a 44% reduction of the tumour size.
For further information, please contact us (Ref 86508-01)
31.03.2015
Health / Therapeutic, Medical Diagnostic 06081-01
10.03.2014
Health / Therapeutic, Other Technologies 00017-04
03.03.2014
Health / Therapeutic 03946-01
30.01.2020
11827-01
06.11.2018
Materials – Coating 07293-01
06.11.2018
Materials – Coating 10581-01
06.11.2018
Chemistry / Environment 08758-01
06.11.2018
11127-01
06.11.2018
Environment and Energy 11107-01