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Peptide protein translation inhibitor and the use thereof for protein translation control

Référence

85498-01

Statut des brevets

French Patent Application: FRO350357 filed on July 21st 2003, entitled “Peptide inhibiteur de la traduction des proteins et ses utilisations pour le contôle de la traduction des protéines”

Inventeurs

Bertrand COSSON
Luc PAILLARD
Vincent LEGAGNEUX
Howard OSBORNE

Statut commercial

Exclusive or non-exclusive licenses.

Laboratoire

Institut de Génétique et Développement de Rennes (IGDR, UMR6061), Rennes, France.

Description

TECHNICAL DESCRIPTION

The inventive peptide protein translation inhibitor is characterised in that the size thereof is greater than 250 amino acids and it comprises an amino acid sequence which is at least for 85% identical to an aminoacid sequence SEQ ID Ndeg.1.

Said invention also relates to a fusion polypeptide which specifically inhibits an interesting target polynucleotide translation which is characterised in that said polypeptide comprises the above defined inhibiting peptide fused with a RNA binding protein.

INDUSTRIAL APPLICATIONS

The principal industrial applications of the invention are the control of the production of proteins of interest as a bioreactor, the control of the production of proteins of interest in cellular therapy (somatic genic therapy) or the control of the production of viral proteins within the framework of antiviral therapies.

 


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