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Method for coupling, in solution, a peptide with at least another compound and uses thereof

Reference

84609-01

Patents status

French patent application FR2797632 filed on August 19th 1999 and entitled “Fonctionnalisation d’un peptide par un groupement alpha-hydrazinoacétique”

Inventors

Olivier MELNYK
Line BOUREL
Dominique BONNET
Hélène GRAS MASS

Laboratory

Institut Biologique de Lille (IBL, UMR8161), Lille, France

Description

TECHNICAL DESCRIPTION

The invention concerns a method for coupling a peptide with at least a compound A, of the non-peptide type, bearing a function selected among the group consisting of carboxylic acid functions and alcohol functions.
The invention is characterised in that said coupling comprises a step which consists in producing, in solution, a hydrazide bond between said peptide and said compound A.
The invention also concerns modified peptides essentially formed by a peptide bound by a hydrazide bond to at least a compound A as defined above, such as a lipid, a sugar, an alcohol or a fluorescent marker, as well as the uses of said modified peptides.
The invention further concerns the use of N,N’-tri(Boc)hydrazinoacetic and N,N’-di(Boc)hydrazinoacetic acids to functionalize a peptide with a alpha -hydrazinoacetic group.

INDUSTRIAL APPLICATIONS

The main applications of this invention are the preparation of synthetic vaccines and reagents of diagnosis which include peptide modified according to the present invention.

For further information, please contact us (Ref 84609-01)

 


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