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30.01.2020
11827-01
06.11.2018
Materials – Coating 07293-01
06.11.2018
Materials – Coating 10581-01
06.11.2018
Chemistry / Environment 08758-01
06.11.2018
11127-01
06.11.2018
Environment and Energy 11107-01
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83879-01
Protected by laboratory know-how
J-F. Moreau, J-L. Taupin and V.Pitard
Non-exclusive know-how licenses
“Immunomodulation par les médiateurs de l’inflammation (IMI)” laboratory, a CNRS laboratory (UMR5140), now called UMR5164, in the Victor Segalen university, Bordeaux 2, France.
The present invention relates to the production and the characterization of several hybridomas which produce monoclonal anti-human GP190 receptor antibodies. Antibodies were obtained using recombinant chimeric or truncated proteins produced in a eukaryotic CHO line. The gp190 transmembrane protein belongs to the hematopoietin family of receptors and is the low affinity receptor for the cytokine Leukemia Inhibitory Factor (LIF). The inventors also developed an ELISA assay to quantify the soluble gp190 receptor, which is naturally produced and retrieved in human biological fluids.
This innovation could be used as a research reagent for the study of the biology of LIF and also of all the other cytokines sharing gp190 as a component of their signal transducing receptor. Diagnosis or therapeutic applications could be possible.
For further information, please contact us (Ref 83879-01)
30.01.2020
11827-01
06.11.2018
Materials – Coating 07293-01
06.11.2018
Materials – Coating 10581-01
06.11.2018
Chemistry / Environment 08758-01
06.11.2018
11127-01
06.11.2018
Environment and Energy 11107-01