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High through-put monodisperse designed microcapsules

Reference

02844-01

Patents status

French patent application FR0955035 filed on July 20th, 2009 and entitled “Procédé de fabrication de capsules, capsules ainsi obtenues et utilisation des dites capsules”

Inventors

Gladys MASSIERA
Manouk ABKARIAN
Etienne LOISEAU

commercial status

Research agreement, exclusive or non exclusive licenses

Laboratory

Laboratoire Charles Coulomb UMR5221 CNRS, Montpellier, France.
http://www.coulomb.univ-montp2.fr/

Description

CONTEXT

Existing high yield processes for producing capsules with a controlled content (size and concentration of the suspended particles) are either difficult and/or expensive to scale-up, limited by a poor control on the size and on the range of accessible sizes, or limited by the  physical properties of the encapsulated fluid (viscosity…).

TECHNICAL DESCRIPTION

The process consists in a one-step method that combine droplet dripping and droplet interface crossing in a single set-up to robustly produce controlled unilamellar vesicles or capsules at high-yield.

BENEFITS

This simple and low-cost process leads to the continuous production of monodisperse vesicles or capsules with respectively a controlled bilayer or shell composition and encapsulated suspension. Physiological media, protein suspensions, colloidal particles or biological cells are exmples of suspensions that can enter the composition of encapsulated suspension. This new high-throughput technique offers unprecedented control on the size  (from 1 to 100 microns), content and permeability of the produced capsules.

INDUSTRIAL APPLICATIONS

Encapsulation for cosmetic, analytical pharmaceuticals

Calibration of medical analyzers

Vectors: drug delivery, blood substitution

Microreactors

For further information, please contact us (Ref 02844-01)

 


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