Find the best CNRS technologies to boost your innovative project.
06.11.2018
Materials – Coating 07293-01
06.11.2018
Materials – Coating 10581-01
06.11.2018
Chemistry / Environment 08758-01
06.11.2018
11127-01
06.11.2018
Environment and Energy 11107-01
19.10.2018
Medical Diagnostic 08504-01
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02616-01
Nanotechnology, Supramolecular system, Molecular scaffold, Building block, Nanowire. Nanomembrane
European patent application n° EP09290826.8 filed on October 10th, 2009 entitled “Multidimensional supramolecular structures essentially made of assembled I-Motif tetramers”
Denis POMPON
Jean-Louis LEROY
Aude LAISNE
Exclusive or non-exclusive licenses, Collaborative agreement
Laboratoire d’Ingénierie des Systèmes Biologiques et des Procédés (LISBP), a CNRS laboratory (UMR5504) in Toulouse, France, http://www.lisbp.fr
In the nanotechnology sector, examples of methodology enabling supramolecular scaffold manufacture have already been done. These methods are mainly based on the auto assembly of « building blocks ». More particularly, DNA based methods are advantageously used because of the its natural properties : programmability of Watson-Crick base-paired secondary interactions, useful both to design branched molecular motifs and to connect them through sticky-ended cohesion. However several drawbacks are associated with self assemblies involving classical Watson-Crick base-paired structures:
Aternate DNA building blocks (“i-motifs”) involving hemiprotonated [Cytidine• (neutral) C+ (protonated)] pairs forming two parallel duplexes mutually intercalated in a head to tail orientation offers the advantage to allow controllable assemblies at room temperature by slight pH shifts modulating base protonation. “I-motifs” made of homopolymer of cytidine can easily self-assemble into large supramolecular structures by successive block addition. However such assemblies are hardly controlable due to the use of a unique molecular block lacking functional diversity.
The present technology is a methodology allowing self-assembly of “i-motifs” into solution or preferably on a surface, thus generating nanostructures of controllable forms and functionalities. The method involves novel semi-synthetic (proteo) nucleic molecular blocks able to self-organise into dynamic polymers on a pH dependant manner. Assembly can be driven by surface features giving rise to organized 2D-structures that can be dynamically rearranged. The supramolecular structure assembly is driven by specialy designed oligonucleotidic sequences including streches of cytidine originally interupted on a suitable manner by other nucleic bases.
Advantages of this method are:
These structures would be usefull for many nanotechnologic applications, including fuel cells, biosensors, living/electronic devices, controled nanoencapsulation.
Different types of building blocks have been developped leading to different self-organised structures. Self-organisation control by surface is curently further investigated in view of combining nanofabrication and self-organisation techniques.
For further information, please contact us (Ref 02616-01)
20.02.2014
Health / Therapeutic, Other Technologies 00017-02
02.10.2013
Medical Diagnostic, Research Tools And Screening 00741-01
02.10.2013
Health / Therapeutic, Medical Diagnostic, Research Tools And Screening 83747-06
06.11.2018
Materials – Coating 07293-01
06.11.2018
Materials – Coating 10581-01
06.11.2018
Chemistry / Environment 08758-01
06.11.2018
11127-01
06.11.2018
Environment and Energy 11107-01
19.10.2018
Medical Diagnostic 08504-01