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Construction and validation of a large focused antibody labrary for intrabody selection

Référence

01477-01

Mots-clés

Focused antibody

Statut des brevets

Unitedd States provisional patent application: US60/894947 entitled “Construction and validaiton of a large focused antibody library for intrabody selection” filed on March 15th, 2007

Inventeurs

Pierre MARTINEAU
Etienne WEISS

Statut commercial

Non-exclusive licenses

Laboratoire

Institut Gilbert-Lauriat : Biomolécules, Biotechnologie, Innovation Thérapeutique, UMR CNRS 7175, in Illkirch, France.

Description

TECHNICAL DESCRIPTION

The subject of the invention is to construct a human scFv library, based on a single framework, optimized for intracellular expression and displayed on filamentous phage.
This invention gives the principles to create a large fully human synthetic scFv library optimized for intrabody selection.

INDUSTRIAL APPLICATIONS

This invention enables to produce a large specific intrabodies characterized by their high stability. It is produced in an expression system making easy their extraction.
These intrabodies have immense potential in the process of drug development and may ultimately become therapeutic entities in their own right.

For further information, please contact us (Ref 01477-01)

 


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