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06.11.2018
Materials – Coating 07293-01
06.11.2018
Materials – Coating 10581-01
06.11.2018
Chemistry / Environment 08758-01
06.11.2018
11127-01
06.11.2018
Environment and Energy 11107-01
19.10.2018
Medical Diagnostic 08504-01
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08758-01
European priority patent application filed on March 11th, 2016 and entitled “ALPHA-HYDROXY-BETA-TRIAZOLO-TETRAZOLES”
US priority patent application filed on March 11th, 2016 and entitled “ALPHA-HYDROXY-BETA-TRIAZOLO-TETRAZOLES”
François COUTY; Bruno DROUILLAT; Pierre QUINODOZ; Karen WRIGHT
Exclusive or non-exclusive license
Collaboration
Institut Lavoisier de Versailles (ILV)
http://www.ilv.uvsq.fr
UMR 8180, Versailles, France
Context
Click chemistry consists in synthezing chemicals via the assembly of smaller modular units. The invention relates more precisely to the CuAAC reaction ; copper(I)-catalysed azide-alkyne cycloaddition.
Technical description
The invention lies in the use of new compounds (alpha-hydroxy-beta tetrazoles) in click chemistry, allowing two ligations thanks to two successive CuAAC reactions.
The first ligation is made with molecule (1), then the alpha-hydroxy-tetrazole group is transformed into an alkyne by EDC (a water-soluble crosslinker) treatment. The second alkyne, called latent alkyne (2), is used for a second CuAAC reaction (3), allowing the addition of a second molecule.
The second alkyne being latent (not in the form of an alkyne during the first ligation) allows the grafting of a different molecule on the latter. This process can be seen as an orthogonal use of click chemistry.
Development stage
Various compounds already synthesized
Benefits
Industrial applications
06.11.2018
Materials – Coating 07293-01
06.11.2018
Materials – Coating 10581-01
06.11.2018
Chemistry / Environment 08758-01
06.11.2018
11127-01
06.11.2018
Environment and Energy 11107-01
19.10.2018
Medical Diagnostic 08504-01