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MOF application: gas of biological interest releasing device

Reference

01741-01

Patents status

French priority  patent application n°FR0852150 filed on April 1, 2008 and entitled « Solide hybride cristallin poreux pour l’adsorption et la libération de gaz à intérêt biologique »

Inventors

Christian SERRE
Russel MORRIS
Patricia HORCAJADA- CORTES
Alexandre VIMONT
Thomas DEVIC
Gérard FEREY

commercial status

Exclusive or non-exclusive license

Laboratory

Institut Lavoisier (ILV, UMR8180), Versailles, France

Description

Metal-organic frameworks (MOFs), also called “hybrid porous crystallised solids”, are coordination polymers with a hybrid inorganic-organic framework comprising metal ions and organic ligands coordinated to said metal ions.

These materials are organised as mono-, bi- or tri-dimensional networks wherein the metal clusters are linked to each other by spacing ligands periodically. These materials have a crystalline structure and are generally porous.

In the present work, the research team has developped porous metal-organic frameworks with or without a modified surface loaded with at least one gas
of biological interest. These MOF solids are capable of adsorbing and releasing gases of biological interest in a controlled manner. 

Among targeted gas of biological interest, one can cite carbon monoxide (CO) and nitric oxide (NO).
It is known that both CO and NO at very low concentrations have an important activity as signaling molecules in the body.

There exists a real need to :

  • develop systems enabling the adsorption and the release of gases of biological interest, in which said systems have a strong adsorption capacity and the release of the gases can be carried out continuously and in a targeted manner
  • have systems which make it possible to deliver, in a controlled manner, the optimum amount of gas necessary for a given application
  • have systems which make it possible to control the duration of release of the gases in a physiological medium
  •  have systems which have sufficient load capacities, especially if repeated gas administrations are envisaged

The present invention aims at answering each of these needs.

Application

  • Antithrombotic equipments (stents, catheters, prosthetic conduits and other medical implants in the body following a surgical procedure)
  • Cosmetic formulations

Pending patents

1741-01

Scope: metal-organic frameworks with or without modified surface with gas loaded.
Priority application: french patent application FR0852150 filled on April 1, 2008 and entitled « Solide hybride cristallin poreux pour l’adsorption et la libération de gaz à intérêt biologique ».
Extensions in Europe, Japan, Canada and USA.

Scientific publications

Angew. Chem. Int. Ed. 2010, 49, 6260 – 6266.

For further information, please contact us (Ref 01741-01)

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